Nosis Bio is a well-funded biotech startup exclusively focused on developing cell-specific RNA therapeutics. We are an all-scientist team of biologists, chemists, and machine learning experts that believe targeted extrahepatic delivery is the only thing preventing RNA therapies from becoming the standard-of-care for most chronic diseases. We combine deep expertise in receptor biology, generative AI, and high throughput in vivo data generation to exponentially accelerate the development of RNA therapeutics for new tissues. We are addressing a major unmet need across the industry and actively partner with pharmaceutical companies, research institutions, and biotech.

We are seeking a RA / Sr. RA / Assoc. Scientist to conduct chemical synthesis and chromatographic purification of proteins, peptides, and oligonucleotides to evaluate the pharmacokinetics (PK) and pharmacodynamics (PD) properties of therapeutic candidates. The successful candidate will have hands-on experience with peptide and/or oligo chemistry and will work closely with multidisciplinary teams to support various drug discovery projects.

• Perform peptide synthesis on Liberty Prime and MultiPep synthesizer
• Perform oligonucleotide synthesis on MerMade 12 synthesizer
• Perform conjugations of oligonucleotides and peptides to various chemical tags (biotin, fluorescent dyes, etc.)
• Perform HPLC purification and MS analysis of synthesized products
• Maintenance of chemistry instruments

What we’re looking for:

• Direct hands-on experience with automated peptide synthesizers (Liberty Prime, MultiPep or similar instruments)
• Experience with automated oligo synthesizers a plus
• Motivated and proactive with strong problem-solving skills
• Ability to multitask and manage several projects simultaneously 
• Team-oriented and open to collaboration across scientific disciplines
• Ability to work on site in our lab space located in the Research Park at Marina Village (Alameda)
• Title is dependent on academic and professional experience – we recruit diverse backgrounds including those with academic, non-profit, and industry experiences!
• RA / Senior RA – Undergraduate and 2+ yrs industry (or similar) experience
• Assoc. Scientist – Master’s degree and 0+ yrs experience OR undergraduate degree and 3+ yrs experience